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KMID : 0615720010180030114
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Jouranl of Korean Acupuncture and Moxibustion society
2001 Volume.18 No. 3 p.114 ~ p.122
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The Effect of Juglandis Semen Aquacupuncture on Urine Concentrating Defect in Glycerol - induced Acute Renal Failure
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Abstract
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Objective : The present study was carried out to determine if Juglandis Semen Aquacupuncture(JSA) exerts beneficial effect against the urine concentrating defect induced by glycerol injection in rabbits.
Methods : In order to test the effect of JSA, rabbits were acupunctured with 0.5㎖ of I%JSA for 7days at both sides of She｀nsu￣(BL23) before the glycerol injection. The other animals were pretreated with an equal volume of saline instead of JSA.
Results : The urine flow was reduced, but the urine osmolality was significantly lower than the basal period in glycerol-injected animals, indicating that glycerol causes the urine concentrating defect. The fractional excretion of Na and K was increased in glycerol-treated animals. The Free-water clearance and fractional water excretion(V/GFR) were increased in animals treated with glycerol.
Conclusion : These results indicate that glycerol injection resulted an impairment in the urine concentrating ability in rabbits. Such changes were prevented by JSA. JSA may be used as a method to treat and prevent glycerol-induced acute renal failure.
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